Shea’s research uses a comprehensive platform approach to assess the convergence of hemostatic dysfunction at the crux of trauma-induced coagulopathy and hemostatic resuscitation. Specifically, Shea designs and builds microfluidic devices to mimic pathological vasculature in order to study hemostasis in flow-dependent environments. Shea focuses on platelet dysfunction in the context of trauma-induced coagulopathy and uses immunofluorescent microscopy to kinetically image clot formation ex vivo. Shea then employs image analysis techniques and develops computer programming approaches to further quantify and explore the resulting mechanistic data. This approach, coupled with the use of both patient data and clinical hemostasis assays, allows for detailed study and discovery of biological phenomena and translation to the bedside. Blood products, which are used to resuscitate hemostasis, also develop compromised function due to an acquired storage lesion. Shea applies these same techniques to study the resuscitative capacity of blood products, including novel products designed for extended storage and targeting specific aspects of hemostatic function. Merging the study of both the basic biology of trauma-induced coagulopathy with the study of blood product functional efficacy and capacity allows for simulation of transfusion ex vivo in a high throughput fashion, with the ultimate goal of transforming the understanding of hemostatic resuscitation and improving outcomes in the trauma patient population.