Events Calendar

16 Sep
Ribosome Hibernation:  A New Molecular Framework of Dormancy in Mycobacteria
Event Type

Lectures, Symposia, Etc.

Topic

Research

Target Audience

Faculty, Graduate Students, Postdocs

University Unit
Department of Infectious Diseases and Microbiology
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Ribosome Hibernation: A New Molecular Framework of Dormancy in Mycobacteria

IDM Seminar Series

Anil K. Ojha, Ph.D.
Research Scientist, Wadsworth Center, Associate Professor, Biomedical Sciences, School of Public Health, University at Albany

Dr. Ojha's lab studies mechanisms underlying mycobacterial persistence against antibiotics. They use biofilms as a growth model in their studies. Biofilms are formed by most microbes including mycobacteria, and are defined as surface-associated, 3D-organized, multicellular communities encapsulated by extracellular matrix.  They hypothesize that inherent heterogeneity in microenvironments of biofilms leads to the development of a specialized subpopulation of cells adapted to extreme nutritional and hypoxic stresses, and that these elite cells develop into persisters. For example, they have observed that zinc depletion in mycobacterial biofilms induce ribosome hibernation, leading to the development of drug tolerant persister cells.

Learn more about their projects and the people behind them. Visit their Projects and People page.

Dial-In Information

Join Zoom Meeting
https://pitt.zoom.us/j/92697108800

Meeting ID: 926 9710 8800
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+12678310333,,92697108800# US (Philadelphia)
8778535247,,92697108800# US Toll-free

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        +1 267 831 0333 US (Philadelphia)
        877 853 5247 US Toll-free
Meeting ID: 926 9710 8800
Find your local number: https://pitt.zoom.us/u/acw99oaq76

Join by SIP
92697108800@zoomcrc.com

Wednesday, September 16 at 12:00 p.m. to 1:00 p.m.

Virtual Event

Ribosome Hibernation: A New Molecular Framework of Dormancy in Mycobacteria

IDM Seminar Series

Anil K. Ojha, Ph.D.
Research Scientist, Wadsworth Center, Associate Professor, Biomedical Sciences, School of Public Health, University at Albany

Dr. Ojha's lab studies mechanisms underlying mycobacterial persistence against antibiotics. They use biofilms as a growth model in their studies. Biofilms are formed by most microbes including mycobacteria, and are defined as surface-associated, 3D-organized, multicellular communities encapsulated by extracellular matrix.  They hypothesize that inherent heterogeneity in microenvironments of biofilms leads to the development of a specialized subpopulation of cells adapted to extreme nutritional and hypoxic stresses, and that these elite cells develop into persisters. For example, they have observed that zinc depletion in mycobacterial biofilms induce ribosome hibernation, leading to the development of drug tolerant persister cells.

Learn more about their projects and the people behind them. Visit their Projects and People page.

Dial-In Information

Join Zoom Meeting
https://pitt.zoom.us/j/92697108800

Meeting ID: 926 9710 8800
One tap mobile
+12678310333,,92697108800# US (Philadelphia)
8778535247,,92697108800# US Toll-free

Dial by your location
        +1 267 831 0333 US (Philadelphia)
        877 853 5247 US Toll-free
Meeting ID: 926 9710 8800
Find your local number: https://pitt.zoom.us/u/acw99oaq76

Join by SIP
92697108800@zoomcrc.com

Wednesday, September 16 at 12:00 p.m. to 1:00 p.m.

Virtual Event

Topic

Research

Target Audience

Faculty, Graduate Students, Postdocs