Events Calendar

Researchers on the Rise: Melanie Grubisha, MD, PhD, and Rui Peixoto, PhD

We are pleased to feature presentations by two of our rising stars, Melanie Grubisha, MD, PhD and Rui Peixoto, PhD as part of our Researchers on the Rise lecture series.

Enhancing NGR/p75/KAL9 Signaling and Impaired Dendritic Morphogenesis in Schizophrenia

Melanie Grubisha, MD, PhD
Assistant Professor of Psychiatry
University of Pittsburgh School of Medicine

Dr. Grubisha participated in the Department of Psychiatry's Psychiatry Research Pathway program as a resident at UPMC Western Psychiatric Hospital (WPH) where her research focused on impairments in dendritic morphogenesis in schizophrenia under the mentorship of Robert Sweet, MD. She then held a postdoctoral appointment, supported by the Training for Transformative Discovery in Psychiatry T32 grant. In 2019 Dr. Grubisha was appointed to the Department of Psychiatry faculty where she is supporting her research activities through a  K08 career development award from the National Institute of Mental Health. In addition to her research, she also sees patients one day per week in a homeless clinic in Pittsburgh.

The Disruption of Basal Ganglia Maturation by Cortical Hyperactivity in Autism Spectrum Disorder

Rui Peixoto, PhD
Assistant Professor of Psychiatry
University of Pittsburgh School of Medicine

Dr. Rui Peixoto's early work as a graduate student demonstrated for the first time that neurologins can be cleaved by fast acting matrix metalloproteases-9 and that this cleavage has a profound impact on synaptic transmission in the brain. After earning a PhD in Neuroscience from Universidade Nova de Lisboa in Portugal, he conducted postdoctoral research in Dr. Bernardo Sabatini’s laboratory at Harvard Medical School that focused on the development of corticostriatal circuits and its implication in ASD. Dr. Peixoto has developed novel approaches for using mouse models to study the pathophysiologies underlying autism. He joined the Department of Psychiatry faculty in January 2019 and is currently the Principal Investigator for a grant sponsored by the Simons Foundation to investigate the disruption of basal ganglia maturation by cortical hyperactivity in Autism Spectrum Disorder. 

Friday, February 7 at 12:00 p.m. to 1:30 p.m.

Western Psychiatric Hospital, 2nd Floor Auditorium 3811 O'Hara St., Pittsburgh, PA 15213