BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Tianyu Zou - Investigating the Genetics of Dental Caries Incid
 ence\, Development Over Time\, and Variability
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20261011T054237Z
UID:tag:localist.com\,2008:EventInstance_39676087177458
DTSTART:20220527T140000Z
DTEND:20220527T160000Z
DESCRIPTION:Department of Human Genetics Doctoral Candidate\, Tianyu Zou\, 
 defends her dissertation on “Investigating the Genetics of Dental Caries
  Incidence\, Development Over Time\, and Variability” \n\nADVISOR: John 
 R. Shaffer\, PhD\n\nCommittee Members:\n\nRyan L. Minster\, PhD\, MSISSeth
  M. Weinberg\, PhDMary L. Marazita\, PhD \n\nABSTRACT:\n\nDental caries is
  the most common chronic disease of childhood\, worldwide\, and is a compl
 ex disease influenced by multiple factors including environmental\, behavi
 oral\, and genetic factors. A better understanding of the etiology of dent
 al caries is needed to improve caries prevention and oral health at both i
 ndividual and population levels. \n\nGenome-wide association studies (GWAS
 s) have been used to explore the genetic basis of dental caries in the pas
 t decade and have reported several genes with plausible biological roles i
 n dental caries. However\, prior GWASs of dental caries used phenotypes co
 llected at a single time point\, which neglected the aspects of caries inc
 idence and development over time. Additionally\, GWASs of quantitative phe
 notypes only tested the genetic effects on the phenotypic mean\, not the p
 henotypic variability. To fill these gaps\, this study performed GWASs usi
 ng phenotypes including time-to-first caries incidence and repeated caries
  measurements at multiple time points\, which were generated from cohorts 
 with longitudinal caries assessments\, and conducted genome-wide scans of 
 heteroscedasticity in dental caries experience followed by targeted gene-b
 y-environment interaction (GEI) modeling. \n\nSpecifically\, genome-wide s
 urvival analysis in Aim 1 showed the genetic underpinnings of caries incid
 ence\, with heritability (i.e.\, the proportion of variance explained by g
 enetics) of time-to- first caries estimated to be 54.5% and 14 association
  signals identified at the suggestive level (P<1E-5)\, some of which were 
 located near genes with potential roles in caries\, including COL5A1\, ASI
 C2\, ESR1. GWAS of repeated dental caries measurements in Aim 2 was the fi
 rst longitudinal GWAS of caries that demonstrated the genetic influence on
  caries development over time. The heritability estimate of longitudinal c
 aries trajectories was 54.7%\, and there were 1 genome-wide (P<5E-8) and 1
 2 suggestive (P<1E-6) associations\, some of which were located near genes
  with potential functions in caries including SOD2\, WNK1\, CTSD\, WWP2\, 
 BTF3.  Genome-wide scans for variance quantitative trait loci (vQTL) – i
 .e.\, genetic variants associated with the variance rather than mean of th
 e trait –in Aim 3 identified variants with genetic effects on caries var
 iability\, which were prioritized for detecting GEI in dental caries. \n\n
 The public health significance of this research is that the results of thi
 s study have broadened our knowledge of the genetic architecture of caries
  onset and development over time\, as well as GEI\, and may provide the fo
 undation for better early detection\, risk assessment\, dental care\, and 
 effective public health interventions.
LOCATION:
SUMMARY:Tianyu Zou - Investigating the Genetics of Dental Caries Incidence\
 , Development Over Time\, and Variability
URL;VALUE=URI:https://calendar.pitt.edu/event/final_phd_defense_-_tianyu_zo
 u_-_investigating_the_genetics_of_dental_caries_incidence_development_over
 _time_and_variability
CATEGORIES:Defenses
END:VEVENT
END:VCALENDAR