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CATEGORIES:Defenses
DESCRIPTION:"Identifying best intervention strategies to mitigate perceived
  physical fatigability severity among older adults with obesity: Leveraging
  data from the EMPOWER Lifestyle Trial"\, Department of Epidemiology\, Scho
 ol of Public Health. \n\nCommittee:\n\nNancy W. Glynn (chair)\, EPIJason Fa
 nning\, Department of Health and Exercise Sciences\, Wake Forest University
 Chaeryon Kang\, Psychiatry\, BiostatisticsBonny Rockette-Wagner\, EPIChrist
 opher E. Kline\, Department of Health and Humna Development\, School of Edu
 cationBarbara J. Nicklas\, Department of Internal Medicine\, Wake Forest Un
 iversity School of MedicineAbstract:\n\nGreater perceived physical fatigabi
 lity (herein fatigability)\, the susceptibility to physical fatigue anchore
 d to specific tasks of quantifiable duration and intensity\, is a deleterio
 us and highly prevalent characteristic among older adults\, preceding disab
 ility and death. Given robust associations with aerobic capacity and physic
 al activity\, fatigability may be modifiable through intervention\; however
 \, current literature lacks evidence in older adult populations and interve
 ntion components have not been well-described. \n\nThis dissertation used d
 ata from the Empowered with Movement to Prevent Weight Regain (EMPOWER) ran
 domized trial to address key knowledge gaps. Highly fatigued (80% prevalenc
 e of more severe fatigability) older adults with obesity participated in on
 e of three physical activity interventions in combination with weight loss:
  1) aerobic exercise (n=60)\, 2) daylong movement (n=63)\, and 3) aerobic e
 xercise and daylong movement (n=60). First\, we examined the time  interve
 ntion interaction on two well-validated measures of fatigability to assess 
 effectiveness of the different interventions. Next\, we examined the mediat
 ion effects of three measures of aerobic capacity and two accelerometer-mea
 sured physical activity metrics on the association between the intervention
 s and fatigability. Finally\, we investigated the associations of fatigabil
 ity with weight outcomes. \n\nWe found that fatigability measured using the
  Pittsburgh Fatigability Scale meaningfully improved during the intensive i
 ntervention period (6-month) and after a 12-month maintenance period. Howev
 er\, there were no significant time  intervention group differences in fat
 igability\, suggesting the three interventions had similar benefits. Mediat
 ion analysis revealed improvements in fatigability may be partially attribu
 ted to lower cost-capacity ratio (a measure of effort during a slow task re
 lative to peak effort) and higher moderate-vigorous physical activity. Fina
 lly\, a clinically meaningful improvement in fatigability was associated wi
 th less weight regain during maintenance. \n\nCollectively\, our work estab
 lishes that fatigability can be modified by diverse physical activity inter
 ventions in combination with weight loss among older adults with obesity. S
 pecifically\, interventions that concomitantly target improving cost-capaci
 ty ratio and moderate-vigorous physical activity may provide the most benef
 it. Lowering fatigability may also be protective in preventing weight regai
 n\, although more research is indicated. Given the numerous age-related hea
 lth consequences associated with greater fatigability\, public health effor
 ts to improve fatigability may promote healthy aging.
DTEND:20260416T150000Z
DTSTAMP:20260511T115514Z
DTSTART:20260416T130000Z
GEO:40.442859;-79.958417
LOCATION:Public Health\, 1155 Public Health
SEQUENCE:0
SUMMARY:Dissertation Defense: Reagan Garcia
UID:tag:localist.com\,2008:EventInstance_52321803704869
URL:https://calendar.pitt.edu/event/dissertation-defense-reagan-garcia
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