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VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Dissertation Defense: Nina Z. Heilmann
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260615T170039Z
UID:tag:localist.com\,2008:EventInstance_49216433342629
DTSTART:20250415T180000Z
DTEND:20250415T200000Z
DESCRIPTION:"Associations of Muscle Function and Size with Falls\, Fall Inj
 uries\, and Bone Density\, Microarchitecture\, and Strength in Older Adult
 s"\, Public Health/Epidemiology. \n\nCommittee: \n\nElsa S. Strotmeyer\, E
 PI (chair)Jane A. Cauley\, EPIKristine M. Ruppert\, EPIBradley C. Nindl\, 
 Department of Sports Medicine and NutritionAbstract:\n\nBackground: Falls 
 and poor bone health increase the risk of fractures\, which affect 1 in 3 
 women and 1 in 5 men aged >50 years globally. Identifying modifiable risk 
 factors\, such as muscle function and size\, is essential for reducing fra
 cture burden in aging. However\, few studies have included multiple measur
 es of muscle function and size to determine which predict falls/fall injur
 ies and bone health. \nObjectives: This dissertation examined associations
  of (1) grip strength and stair climb power with recurrent and injurious f
 alls longitudinally\; (2) grip strength and jump power with longitudinal c
 hanges in bone density\, microarchitecture\, and strength using high-resol
 ution peripheral quantitative computed tomography (HR-pQCT)\, and (3) whol
 e-body muscle mass and thigh muscle volume with HR-pQCT measures cross-sec
 tionally. \nMethods: Participants included: (1) women from the Study of Wo
 men’s Health Across the Nation (N=1719\, age 65±3 years)\, (2) men from
  the Osteoporotic Fractures in Men Study (N=225\, age 83±3 years)\, and (
 3) women and men from the Study of Muscle\, Mobility and Aging (women: N=1
 81\, men: N=118\, both aged 76±4 years). Generalized estimating equations
  estimated longitudinal odds of recurrent and injurious falls\, while mult
 ivariable linear regression examined associations with bone parameters.\nR
 esults: Higher grip strength\, but not stair climb power\, was associated 
 with lower odds of injurious falls\, but not recurrent falls\, in middle-a
 ged and older women (6.6±0.3 years follow-up). Higher grip strength\, but
  not jump power\, was associated with changes in tibial bone area in older
  men (6.2±0.6 years follow-up). Cross-sectionally\, greater whole-body mu
 scle mass was associated with higher bone strength in older women\, but no
 t men\, while greater thigh muscle volume was associated with higher bone 
 strength in both sexes. \nConclusion: These findings identify higher grip 
 strength as a predictor of lower fall injury risk and bone adaptation\, su
 pporting its utility as a simple and practical measure of muscle function 
 in aging populations. Sex-specific associations between muscle size and bo
 ne strength highlight the need for further research into muscle-bone inter
 actions in populations of both women and men. These results may guide musc
 uloskeletal interventions targeting muscle strength and size to reduce the
  public health burden of falls and fractures.
GEO:40.4474;-79.952894
LOCATION:Bellefield Professional Building\, 324
SUMMARY:Dissertation Defense: Nina Z. Heilmann
URL;VALUE=URI:https://calendar.pitt.edu/event/dissertation-defense-nina-z-h
 eilmann
CATEGORIES:Defenses
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